Lynch Syndrome Genetic Testing in India: Early Detection for Hereditary Cancer Risk
Lynch syndrome is one of the most common inherited conditions that increase a person’s risk of developing certain cancers, especially colon cancer and endometrial (uterus) cancer. It is caused by changes in specific genes passed down from one generation to the next. According to global estimates, Lynch syndrome accounts for about 2 to 3 percent of all colorectal cancer cases .
Despite its impact, many people remain unaware that cancer can sometimes occur in families due to inherited gene mutations. The encouraging part is that with the help of Lynch syndrome genetic testing, individuals can now detect their inherited cancer risk early and take preventive steps.
In this blog, you will learn what Lynch syndrome is, who should get tested, how testing is done, and how Yoda Diagnostics supports people who want to take action against hereditary cancer.
What Is Lynch Syndrome and Why Is Genetic Testing Important?
Lynch syndrome, which is also called Hereditary Non-Polyposis Colorectal Cancer or HNPCC, happens because of changes in certain genes that protect our body from cancer. These genes are known as mismatch repair genes. Their job is to fix mistakes that happen when our cells divide and grow. When these genes stop working properly, the mistakes in the cells build up, and this can lead to cancer.
The problem with Lynch syndrome is that people who have it do not know they are at risk until someone in the family gets cancer. The cancers linked to Lynch syndrome mostly include colon cancer, uterus cancer (endometrial cancer), ovary cancer, stomach cancer, urinary tract cancer, and sometimes other types.
Lynch syndrome is passed from parents to children. If one parent has Lynch syndrome, there is a 50 percent chance that each child will have it too. This is why testing for inherited cancer risk is very important.
Cancers Associated with Lynch Syndrome
When a person has Lynch syndrome, the chance of getting certain cancers is much higher than for people without the syndrome. These cancers often appear at a younger age. Below is a list of cancers linked to Lynch syndrome and how common they are among people with this condition.
- Colon cancer: Most common in Lynch syndrome. Often develops at a younger age than usual.
- Uterine (Endometrial) cancer: Common in women with this condition. May occur early in life.
- Ovarian cancer: Less frequent but still more likely than in the general population.
- Stomach cancer: Seen more often in people with Lynch syndrome than others.
- Urinary tract cancer: Affects areas like the kidneys or ureters more frequently in these individuals.
- Other cancers: There may also be a higher risk of pancreatic, brain, or certain skin cancers.
This is why doing genetic testing for hereditary cancer can help people plan early check-ups and prevent these cancers.
Who Should Consider Genetic Testing for Lynch Syndrome?
Not every person needs to do genetic testing. But doctors suggest testing in certain cases. You should think about colon cancer genetic testing or Lynch syndrome genetic testing if:
- You had colon cancer or uterus cancer before the age of 50.
- There are two or more close family members with cancers related to Lynch syndrome, such as colon, uterus, ovary, or stomach cancer.
- A test on your tumour shows signs like microsatellite instability or loss of mismatch repair proteins.
- Someone in your family has already tested positive for Lynch syndrome gene mutation.
It is always recommended to speak to a doctor or ask for genetic counseling for Lynch syndrome to understand your risk.
How is genetic testing for Lynch syndrome done
Lynch syndrome testing is done through a blood or saliva sample. The sample is sent to a genetic testing lab in India that checks for changes in mismatch repair genes such as MLH1, MSH2, MSH6, PMS2, and EPCAM.
The steps involved are:
- Tumour testing – If cancer is already present, the doctor may first check the tumour for signs like microsatellite instability or mismatch repair protein loss.
- Germline testing – This is done through blood or saliva to check if the person was born with the gene change.
- Cascade testing – If a person has Lynch syndrome, other family members are advised to get tested as well.
In India, you can now find trusted centres for Lynch syndrome testing in Hyderabad and other major cities.
What to Do if You Test Positive for Lynch Syndrome
If a person tests positive for Lynch syndrome, it does not mean they already have cancer. But it does mean they have a higher risk. The following steps can help reduce this risk
- Regular colonoscopy tests – These should begin as early as age 20 to 25 and be done every one or two years.
- Preventive surgeries – Some women may choose to have surgery to remove the uterus or ovaries after they finish having children.
- Other cancer screenings – Doctors may suggest tests for stomach, urinary tract, or other cancers.
- Taking a low dose of aspirin – Some studies show this may reduce the chance of getting colon cancer.
- Lifestyle changes – Eating healthy, exercising, and avoiding smoking can also help.
These steps can save lives by catching cancer early or preventing it.
How Yoda Diagnostics supports inherited cancer risk management
Yoda Diagnostics is a leading cancer genomics lab in Hyderabad that provides full support for families worried about inherited cancer risk.
Their services include
- Hereditary cancer panel in India covers all important genes linked to Lynch syndrome
- Accurate testing through next generation sequencing
- Genetic counseling for Lynch syndrome before and after testing
- Support for cascade testing so that family members can also get tested
- Reports that meet NABL and ISO standards for trust and quality
- Quick reporting and support for doctors across India
If you are searching for where to test for Lynch syndrome or a trusted inherited cancer testing lab, Yoda Diagnostics can guide you at every step.
Conclusion
Lynch syndrome runs in families and increases cancer risk. But by doing genetic testing for hereditary cancer at the right time, you can take steps to protect your health and your family’s future.
If cancer runs in your family, do not delay. Talk to a doctor about genetic testing. Get tested at a reliable genetic testing lab in India like Yoda Diagnostics. Early action can save lives.
